August 2012 — Present
Delineated early lineage developmental steps of innate-like T cells.
The ability of innate-like T cells to quickly mount a strong immune response makes them attractive for cell-based therapies. However, inadequate understanding of their development has prevented the therapeutic manipulation of these cells beyond early phases of clinical trials. We have demonstrated a key role of E proteins in promoting the development and expansion of innate-like populations, which can provide new strategies for controlled applications of these cells.
Specialized skill sets: Murine models, CRISPR/Cas technology, ChIP-Seq, RNA-Seq, large data set bioinformatics analysis, FACS analysis