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Jessica Von Stetina

Jessica Von Stetina

Postdoctoral Fellow, Laboratory of Dr. Terry L. Orr-Weaver

Whitehead Institute/MIT

Greater Boston Area, us

Broadly-trained neuro-, cellular and molecular biologist with vast experience with different experimental systems. Skilled in high-throughput genomic sequencing techniques. Strong expertise in biochemical and genetic screening, assay development, and a wide array of molecular and cell based assays. Successful in performing te...

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Whitehead Institute/MIT

Postdoctoral Fellow, Laboratory of Dr. Terry L. Orr-Weaver

Focus: Genetic and genomic studies of polyploidy in mouse blood cells and Drosophila nervous system glia cells

• Discovered that variant cell cycles differentially control polyploidy-induced growth of blood-brain barrier-forming glia cells in the nervous system during normal development

• Made the unexpected finding that in addition to increases in DNA content, nuclear number also affects glial cell size

• Established that the mechanism of polyploidization in glia is tightly regulated and critical for proper blood-brain barrier function

• Identified two major signaling pathways that control polyploidy-driven growth in nervous system glia cells

• Defined the transcriptomes for polyploid cells from Drosophila embryonic and adult ovarian and glial tissues

• Determined that polyploid mouse blood megakaryocytes have a fully replicated genome, in contrast to most polyploid cells